They also provide insight into the link between micro-RNA dysregulation and genetic liability to schizophrenia and cognitive dysfunction. Our findings inform the cortical synaptic and neuronal mechanisms of working memory impairment in the context of psychiatric disorders. Reduction in Dgcr8 levels appears to be a major driver of altered short-term synaptic plasticity in prefrontal cortex and working memory but not of long-term plasticity and cytoarchitecture. We confirmed the pronounced DiGeorge critical region 8 ( Dgcr8)-dependent deficits in primary micro-RNA processing and identified additional changes in gene expression and RNA splicing that may underlie the effects of this mutation. Apart from previously reported reduction in dendritic complexity of layer 5 pyramidal neurons, altered synaptic plasticity occurs in the context of relatively circumscribed and often subtle cytoarchitectural changes in neuronal density and inhibitory neuron numbers. BookHematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases. The Markx lab is currently carrying out a number of groundbreaking studies that focus on introducing a precision medicine-based approach to psychiatry. After graduation, he joined the Columbia Psychiatry faculty and was named the Director of Precision Psychiatry. Find contact's direct phone number, email address, work history, and more. Guided by cognitive deficits, we demonstrated that mutant mice display robust deficits in high-frequency synaptic transmission and short-term plasticity (synaptic depression and potentiation), as well as alterations in long-term plasticity and dendritic spine stability. He completed his residency in psychiatry at Columbia University. View Sander Markx's business profile as Assistant Professor of Clinical Psychiatry at Columbia University. We used a mouse model of the schizophrenia-predisposing 22q11.2 microdeletion to evaluate how this genetic lesion affects cortical neural circuits at the synaptic, cellular, and molecular levels.
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